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KMID : 1123920190330020141
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Korean Journal of Oriental Physiology and Pathology
2019 Volume.33 No. 2 p.141 ~ p.150
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Yeosin-san Increases Female Fertility through Inducing Uterine Receptivity and Ovarian Functio
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Choi Hee-Jung
Joo Bo-Sun
Park Mi-Ju
Park Min-Jung
Bae Bo-Ram
Kim Bo-Sung
Park Hye-Rin
Kim Keuk-Jun
Yang Hee-Jin
Yoo Jeong-Eun
Chung Tae-Wook
Joo Jong-Kil
Ha Ki-Tae
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Abstract
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Despite the development of assisted reproduction technologies (ART) including in vitro fertilization (IVF), the poor ovarian response and endometrial receptivity remains clinically a major unmet need. Although these problems are difficulties to solve in infertility treatment, there are no good therapeutic option yet. Traditional herbal remedies and acupuncture, therefore are being proposed as alternative treatment. Our group found that traditional herbal medicines such as Paeonia lactiflora L.(PL, 芍藥), Cyperus rotundus L.(CR, 香附子), and Perilla frutescens (PF, 紫蘇葉) could improve endometrial receptivity. In this study, we found out Yeosin-san (如神散) as an optimal herbal formula via combination of the previously established herbal medicines. Yeosin-san is a traditional Korean medical formula which was established by Ziming Jin (陳自明) and recorded in Furendaiquanliangfang (婦人大全良方) at first. The formula traditionally used for treating abnormal uterine bleeding and leukorrhea. It showed a highest effect on leukemia inhibitory factor (LIF) expression and on the adhesion between trophoblastic cells and endometrial cells. In addition, it has been shown that the Yeosin-san not only increases the endometrial receptivity to improve the embryo implantation but also enhances the ovary function by expressing the angiogenesis-related genes. Here we suggest that Yeosin-san could be a novel and effective candidate for treating female infertility.
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KEYWORD
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Yeosin-san, Fertility, Embryo implantation, Cell adhesion, Leukemia inhibitory factor (LIF)
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